\/p>","gtin13":"0758381476494","image":["https:\/\/siteimgs.com\/10017\/item\/brite-rendering_1703084216-0.jpg"],"brand":"EvoMuse","url":"https:\/\/www.dpsnutrition.net\/i\/28735\/evomuse-brite-capsules-120-cap.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"59.99","url":"https:\/\/www.dpsnutrition.net\/i\/28735\/evomuse-brite-capsules-120-cap.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/OutOfStock"}},{"@type":"Product","name":"EvoMuse Brite Capsules - 360 Capsule (2 x 180 Capsule Bottles) TWINPACK *New Formula","sku":"EM2036","description":"
BRITE | Adipocyte Conversion Formula<\/p>\r\n
\"A cold, starving animal doesn't care about a 6-pack.\"<\/p>\r\n
Perspective is a complex thing. From the perspective of an undisciplined modern human, life is surrounded by plenty and our worries can consist of trying to reach our most aesthetically pleasing selves. However, perspective for most of the creatures on the planet is harsh, difficult, and a never-ending quest for precious resources.<\/p>\r\n
Heat is one of the most precious resources, as the universe contends with \"hot spots\" in its quest to finally attain perfect order and energy distribution – namely heat death.<\/p>\r\n
Nature, on the other hand – if it can be separated from the Universe – seems obsessed with continuing bright hot spots of life, without caring about individuals. The mechanistic viewpoint of our bodies, which still reigns supreme, follows laws of thermodynamics and thus life and heat can almost be interchangeable.<\/p>\r\n
As we have covered countless times, humans, in our dominant but highly artificial state, are an aberration from the general rules. Nature drives numerous animals into dormancy when resources become scarce and more energy would be spent finding calories (heat, fuel) than could be replenished. Hibernation is the name of the game for Winter. Hibernation must be prepared for, which is why hibernating animals begin gorging and getting fat during Fall. Those fat stores are our point of interest, as much of it is stored in specialized cells.<\/p>\r\n
The key to thermogenesis is adrenergic signaling (meaning related to adrenaline and noradrenaline). While humans have come to rely more on B2 (and A2) signaling for active lipolysis resulting in ATP formation with increases in heat a secondary effect (to fuel activity), the animals that hibernate during cold weather rely on different receptors (B3, A1) to generate heat via thermogenesis to go along with a more passive release of adrenaline\/noradrenaline, since for the most part they aren't moving much.<\/p>\r\n
Human B3 receptors have lost importance, which means the first step is to increase activity here…<\/p>\r\n
…but before we do that, let's take a quick step back for all those who are new to this here do-si-do.<\/p>\r\n
A full decade ago, Evolutionary Muse released a first-in-kind product designed to facilitate the browning of white fat. Aptly named BRITE™, it shares the same name as those adipocytes which are named for being BROWN-IN-WHITE cells – white adipocytes which behave like brown adipocytes. Brown adipocytes are metabolically active cells which use their fat stores to generate body heat...the life hack of all life hacks, if you will. But there was one glaring problem – modern living was all but making this phenomenon a thing of the past. No problem, we should just reject modernity and embrace tradition. Right?<\/p>\r\n
Wrong.<\/p>\r\n
Evolutionary Muse: Inspire to Evolve. (Translation: We take a pill for that now.)<\/p>\r\n
DIFFERENCE BETWEEN WAT AND BAT<\/p>\r\n
BAT works quite differently, if not opposite, to White Adipose Tissue (WAT). BAT is dense in mitochondria and considered a highly thermogenic fat cell, responsible for creating heat through a process called “non-shivering thermogenesis”. This process burns calories through a futile cycle of shuttling protons to the mitochondria to generate heat. WAT, however, is what we all think of when we hear the term “body fat”. It stores calories so they can be used later during periods of hunger or famine, and secretes various adipokines.<\/p>\r\n
Even more recently, we have discovered another player in the adipocyte story – Brown-in-White cells, or “BRITE”. At a microscopic level, these cells display a color between brown and white, and behave in a similar thermogenic fashion to BAT cells. While we don’t know yet if reduced thermogenic activity is a cause or consequence of obesity, we do know that an increase in BAT and\/or brite cells improves glucose tolerance and insulin sensitivity.<\/p>\r\n
Two distinct pathways exist towards increasing brite cells in adult humans, (1) triggering precursor cells into becoming brite cells, and (2) turning mature WAT cells into brite cells. We want to target these pathways directly so that we can increase the ratio of brite cells to WAT cells, allowing your body to constantly burn more calories. So, let’s dive into some of the known methods of brite cell creation and activation.<\/p>\r\n
COLD THERAPY, B3 ADRENERGIC ACTIVATORS<\/p>\r\n
Cold exposure triggers macrophages in BAT to produce catecholamines like norepinephrine. Norepinephrine agonizes b-adrenergic receptors on fat cells. Cold also activates beige cell development and function. The effect can be mimicked with B3 adrenergic activators, which also trigger PGC-1a and brite cell development. It can also be mimicked with TRPM, or cold-sensor activators.<\/p>\r\n
IRISIN AND PGC-1 ALPHA<\/p>\r\n
Exercise causes increased expression in muscle of PPARg coactivator 1-alpha (PGC-1a), which downstream results in a hormone\/myokine called irisin. This irisin contributes to a browning of WAT cells. So not only does exercise burn calories directly, but also secondarily through triggering the browning process with irisin. Fortunately, this is an exploitable angle independent of exercise by triggering the PPARg cascade.<\/p>\r\n
PRDM16, BMP-7<\/p>\r\n
Prdm16 is a transcriptional cofactor, substantially enriched in human BAT compared to adjacent WAT. It acts by binding to and modulating other factors like C\/EBPb, PPARy, PPARa, and the aforementioned PGC-1a. Knocking out Prdm16 negates the thermogenic effect of brown cells, and increases WAT. Considered a key driver of brown fat cell fate, this cofactor is quite important. Bone Morphogenetic Protein-7 (BMP-7) increases expression of Prdm16 in precursor cells, and is essential for brown fat development. BMP-7 is fortunately something we can target with supplementation.<\/p>\r\n
ADENYLYL CYCLASE AND ALPHA-1 ADRENERGIC ACTIVATION<\/p>\r\n
Adenylyl cyclase is an enzyme that catalyzes the conversion of ATP to cyclic AMP. We mentioned beta-adrenergic receptor agonism, but it turns out this is greatly enhanced with simultaneous adenylyl cyclase upregulation and alpha-1 activation. So, targeting adenylyl cyclase, alpha-1, and beta-adrenergic agonism together causes enhanced brite cell creation.<\/p>\r\n
UCP1<\/p>\r\n
BAT mitochondria respond to something called UCP1 (uncoupling protein 1) to burn fat and generate heat, while brite cells seem to express lower levels of UCP1. However, brite cells potentially burn fat independently of UCP1 signaling, and furthermore, with the proper triggers, brite fat can actually turn on high levels of UCP1. Multiple ingredients in the BRITE formula will encourage WAT cells to upregulate UCP1 levels. Some of you may be familiar with a somewhat popular drug in the bodybuilding community years ago called DNP (which actually has roots in the 1930s as a weight loss drug). DNP was meant to mimic activated UCP1, which drastically elevated thermogenesis. While extremely effective, unregulated uncoupling can (and did) cause hyperthermia and death. Fortunately, we now have effective ways of targeting UCP1 safely.<\/p>\r\n
PHOSPHODIESTERASES<\/p>\r\n
Phosphodiesterases (or PDEs from here on out) are a family of enzymes that catalyze the inactivity (and therefore homeostasis) of the cAMP and\/or cGMP systems. An example we should all be familiar with is PDE5, which reduces cGMP in the erectile tissues, suppressing erectile response. Viagra, Cialis, etc., all inhibit the PDE5 enzyme, which leads to accumulation of cGMP, relaxation of penile tissues, dilation of blood vessels and eventually an erection.<\/p>\r\n
The cAMP and cGMP systems are tightly controlled by physiological signals in order to maximally preserve resources. The cAMP system, for example, is related to energy states using Adenosine as a backbone (think highly depleted ATP – Adenosine Triphosphate). Elevation of cAMP leads to lipolysis, the freeing of fatty acids for transport to metabolically active tissue for either conversion to ATP or, in our case, thermogenesis.<\/p>\r\n
There are two members of the PDE family that are of interest to us. One is PDE3b, the enzyme form activated by insulin to suppress lipolysis, allowing for the opposite to occur (storage of fat\/carbs). By suppressing PDE3b, we preserve a state of lipolysis and fat continues to be \"burned\" even after eating. Inhibition of PDE3b also removes the barriers of induction of UCP1, which causes non-shivering thermogenesis (the use of fatty acids to generate heat).<\/p>\r\n
The other member is a newer player, PDE4D. Working hand-in-hand with PDE3b inhibition, PDE4D inhibition amplifies adrenergic signaling, UCP1 expression, lipolysis, and amplification of thermogenesis – especially basal (baseline) levels which means the rate of lipolysis without additional stimulation. The higher the basal rate, the more fat burned\/heat generated.<\/p>\r\n
At the end of this inhibition, we go back to that Adenylyl Cyclase (and in the case of cGMP, Guanylyl Cyclase) creating the energy usage and replenishment cycle.<\/p>\r\n
INGREDIENTS AND FUNCTION<\/p>\r\n
Butcher’s Broom 50:1 Extract<\/p>\r\n
Butcher’s Broom is a herb also known as Ruscus aculeatus. It gets its name from the practice of butchers using it for its supposed antibacterial properties to clean their cutting boards. It has been used in traditional medicine for its vasoconstrictive and anti-inflammatory actions (reducing swelling, preventing hemorrhoids, etc.).<\/p>\r\n
The plant contains a variety of saponins, which have been shown to activate alpha-1 adrenergic receptors and stimulate the release of norepinephrine. It also has a protective effect on capillaries, strengthens blood vessels, and helps maintain healthy circulation.<\/p>\r\n
As discussed previously, this alpha-1 activation is important and has been shown to shift preadipocytes to beige cells as opposed to white adipose tissue. As well, recent research shows that when hibernating, animals’ thermosensitive mechanisms will detect ambient and body temperatures and, if falling under threshold, the SNS will release norepinephrine to activate BAT in order to maintain viable body temperatures.<\/p>\r\n
Gypenosides (75%)<\/p>\r\n
Gypenosides are saponins found in the jiaogulan plant. This ingredient targets both WAT and BAT. With it we get WAT browning and an increase in fat oxidation genes in both WAT and BAT. Obesogenic diet mice treated with Gypenosides had a significantly reduced bodyweight vs. control, with lower cholesterol and insulin resistance. Gypenosides potently activate AMPk, which is tied directly to the cGMP\/cAMP systems and sympathetic\/parasympathetic nervous systems (metabolic autopilots), and amplify the lipolytic\/thermogenic effects on brite cells.<\/p>\r\n
Menthol Crystals<\/p>\r\n
Aside from B3 adrenergic receptor activation, the other most important way to start the browning process of WAT browning, as previously discussed, is through cold exposure. By exposing the body to cold temperatures long-term, it activates the TRPM8 receptor, which triggers browning in order to more effectively use WAT to create body warmth.<\/p>\r\n
TRPM8 activation also enhances the thermogenic function of brown adipocytes through UCP1 and the b-adrenergic pathway.<\/p>\r\n
So Menthol mimics long-term cold exposure by activating the TRPM8 channel, which has been shown to induce WAT browning as well as an upregulation in BAT thermogenesis. This has been shown to increase core temperature, reduce body fat and improve glucose metabolism.<\/p>\r\n
Vanillin<\/p>\r\n
An ingredient used in fake vanilla extracts for baking, Vanillin (and its metabolite Vanillic Acid) are metabolic derivatives from Anthocyanins. In addition to favorably reducing the ratio of Firmicutes to Bacteroides, resulting in a favorable gut environment for fat loss, Vanillin potently induces both browning of white fat and expression of UCP1.<\/p>\r\n
Vanillin also increases glucose uptake in muscle tissue as well as regulating redox imbalances and inflammation.<\/p>\r\n
Black Pepper Extract (20% Piperine)<\/p>\r\n
TRPV1 is a capsaicin and vanilloid receptor in the body that is responsible for detection and regulation of body temperature and pain. More recently this receptor has been identified as a major player in obesity and body fat regulation. Stimulation of TRPV1 has been shown to upregulate BAT and increase fat oxidation and energy expenditure. TRPA1 is a similar receptor that functions to recognize cold and pain. Piperine, as well as several other compounds in black pepper, have been shown to be TRPV1 and TRPA1 agonists, with an even greater efficacy than capsaicin.<\/p>\r\n
Trans-Cinnamaldehyde<\/p>\r\n
Trans-Cinnamaldehyde is a pungent compound from cinnamon or dried cassia bark. It has been shown to increase UCP1 in both WAT and BAT, inducing browning of WAT cells. It also activates the cold receptor TRPA1. Back to those rodents fed obesogenic diets, Trans-Cinnamaldehyde inhibited hypertrophy of adipose cells, decreased body fat (including visceral fat), decreased voluntary food intake, and improved insulin sensitivity.<\/p>\r\n
Salvia Miltiorrhiza 20:1 (Ethanol Extract)<\/p>\r\n
Salvia Miltiorrhiza is a fascinating plant containing potent compounds that inhibit an enzyme called DGAT (diacylglycerol acyltransferase). Salvia Miltiorrhiza is able to prevent the final step in esterifying lipids into the form that WAT need them in – namely triacylglycerides (triglycerides). This keeps the lipids circulating in the bloodstream to be picked up and used by peroxisomes and mitochondria, and thrown off as heat.<\/p>\r\n
Salvia Miltiorrhiza also inhibits SMAD2\/3 expression (see the BMP writeup), which suppresses myostatin activity and preserves muscle mass.<\/p>\r\n
Salvia Miltiorrhiza has a dramatic effect on mitochondrial function in brite cells, basically turbocharging their activity by amplifying UCP1 activity.<\/p>\r\n
Rutaecarpine<\/p>\r\n
Contained in large quantities in the evodia fruit, it was first thought the Evodiamine was the compound responsible for the increase in non-shivering thermogenesis. Evodiamine turned out to be a huge disappointment, because it turns out the Rutaecarpine was what we were looking for.<\/p>\r\n
Potently activating both AMPk and PGC-1a, Rutaecarpine also very strongly increases thermogenesis as well as mitochondrial biogenesis in brite cells. The more mitochondria, the more uncoupling and thus more thermogenesis and more fat burned.<\/p>\r\n
Rutaecarpine also inhibits adipogenesis and lipogenesis, preventing lipid accumulation in WAT. Remember lipids in WAT have to be removed through a process of lipolysis before they can be transferred to metabolically active tissue and organelles (peroxisomes, mitochondria). By preventing WAT from accumulating lipids as well as crippling the body’s ability to simply make more white fat cells, all while shutting the lipids into the metabolically active brown\/brite fat cells, the process of thermogenesis becomes more efficient.<\/p>\r\n
Sesamol<\/p>\r\n
Sesamol is a phenol derivative of sesame oil with antioxidant and anti-inflammatory properties. This is another ingredient in the formula with the aforementioned two-pronged attack. It downregulates adipogenic differentiation factors (C\/EBPa, PPARy, SREBP-1) and decreases fat accumulating enzymes like fatty acid synthase (FAS), while upregulating fat oxidizing enzymes like HSL, LPL and AMPk. In mice on an obesogenic diet, it decreased fat mass and adipocyte size in both WAT and BAT by increasing UCP1 and PCG-1a.<\/p>\r\n
Borneol<\/p>\r\n
Borneol is a very potent P-glycoprotein efflux pump inhibitor. While “distracting” the P-gp pump, the ingredients of BRITE are able to enter the body unhindered by this physiochemical saboteur. As an additional benefit, Borneol also activates the TRPM8 cold receptor.<\/p>\r\n
Myricetin-Nicotinamide Crystalline Complex<\/p>\r\n
The primary superstar of the new formula, Myricetin is an incredibly diverse and hugely potent ingredient.<\/p>\r\n
Let’s do a quick functional run through.<\/p>\r\n
GLP-1 agonist – GLP-1 agonists are all the rage for weight loss right now. GLP-1 stands for Glucagon-like Peptide 1. Initially targeted to reverse type 2 diabetes, GLP-1 agonists soon manifested an interesting secondary effect – massive and rapid fat loss. As research gains traction, several explanations are emerging. A potent appetite suppression pathway, GLP-1 appears to be extremely active in the brain, activating brain-specific AMPk (hypothalamus, etc.) and stimulating central activation of brown\/brite fat thermogenesis. They also are highly active in increasing muscle-specific glucose uptake, and are effective at improving cardiac function. GLP-1 agonists are inactivated by something called dipeptidyl peptidase-4 (DPP-4). Interestingly enough, Myricetin inhibits DPP-4, thus amplifying and prolonging its own effect.<\/p>\r\n
Myricetin has also been shown to be incredibly potent at inducing brite cell conversion, activating non-shivering thermogenesis, and dramatically increasing mitochondrial biogenesis (formation of new mitochondria).<\/p>\r\n
GSK3b – Touched on briefly in the TopMuscle writeup, Glycogen Synthase Kinase 3b functions to inhibit a ton of growth associated positive effects in the body. This includes muscle growth, glycogen formation, and most importantly, brown\/brite fat thermogenesis. In fact, its potency at shutting down non-shivering thermogenesis is stunning. As luck (or design) would have it, Myricetin is the most potent GSK3b inhibitor so far found in natural form, with an IC50 of 900 nanomoles – incredibly potent.<\/p>\r\n
PDE3b – as mentioned elsewhere, in order for BAT\/BRITE thermogenesis to be maximized, both PDE3b and PDE4D need to be inhibited. As if Myricetin hasn’t already shown to be badass, it also inhibits PDE3b.<\/p>\r\n
Myricetin sounds great – let’s toss that in. Well, being a flavonoid, Myricetin has one of the worst oral absorption profiles I’ve ever seen, at very low single digit %. Other absorption enhancing methods (cyclodextrin, etc.) also turned out to be disappointing. However, I worked out a crystallization process with Nicotinamide that yielded some absolutely gorgeous, and highly absorbable, crystals – enabling us to include this spectacular ingredient in the formula.<\/p>\r\n
The best part? Nicotinamide is also a highly potent brown fat activating ingredient, by both amplifying adrenergic signaling at the B3 receptor and by triggering mitochondrial biogenesis, as well as increasing expression of PPARa and PGC-1a.<\/p>\r\n
Fucoxanthin 40%<\/p>\r\n
Fucoxanthin is a simple ingredient. It dramatically increases expression of UCP1, which should be clear by now.<\/p>\r\n
Ginger-6 Specialized Extract (std for 6-Paradol, 6-Shogaol, 6-Gingerol)<\/p>\r\n
Ginger is absolutely one of the most popular plants for digestion, soothing a dysfunctional stomach, and tossing back after sushi and wasabi. It is also popular for fat loss, though in previous usages sort of haphazardly tossed in. I’m sure you’ve also seen something called Grains of Paradise (6-Paradol) used in competing formulas, though with highly mixed, often disappointing results. Turns out, if you know the correct solvents to use and in what order, you can extract the 3 main “browning” compounds from Ginger in high concentrations.<\/p>\r\n
6-Paradol – As mentioned it has become a commonly used ingredient. Another compound used to increase WAT browning, 6-Paradol also increases expression of PCG-1a and UCP1, resulting in increased thermogenesis with measurable temperature increases in brite\/brown adipose. However, of the three it appears to be the weakest.<\/p>\r\n
6-Shogaol – The immediate precursor of 6-Paradol, 6-Shogaol shows extreme promise as a thermogenic and browning agent, both in mature and preadipocytes. Increasing expression of the usual suspects (PCG-1a, UCP1), 6-Shogaol also increases mitochondrial turnover and biogenesis, increases the binding energy of ligands in the essential B3 adrenoreceptors (amplified signaling), and provides for a dramatic upregulation of beige markers, indicating significant browning of WAT.<\/p>\r\n
6-Gingerol – Along with 6-Shogaol, the most dominant compound in ginger – and the most potent. Sharing functionality with 6-Shogaol (all pathways similarly, but more potently, activated), 6-Gingerol also inhibits lipogenesis. 6-Gingerol also shows an extremely potent ability to break the giant lipid droplet which characterizes WAT into smaller, multiple droplets – enabling the shift to classical brite characteristics more easily.<\/p>\r\n
Humulus Japonicus Extract 50:1 (Water)<\/p>\r\n
Humulus Japonicus Extract is a new and exciting addition to the formula. In addition to inducing browning of WAT, it exerts potent antioxidant effects and increases expression of both AMPk and UCP1, as well as being a decent PPAR-delta agonist. The difference in hibernating animals using more PPARa to provide mitochondrial substrate in the liver is that they generally spend the winter dormant, whereas humans have the added benefit of physical motion, thus adding PPAR-delta, which is dominant in skeletal muscle, to the mix.<\/p>\r\n
Quercetin-Theobromine Crystalline Complex<\/p>\r\n
An absolute thermonuclear addition to the new formula is an ingredient combination I’ve been trying to fit for years, and this is an incredibly fortuitous (that means lucky) addition. Though they are grown together into a crystalline complex, which mostly enhances absorption by several fold, we will take each ingredient separately.<\/p>\r\n
Quercetin – The Big Q is an extremely common compound in most plants. In addition to acting as a potent zinc ionophore (escort molecule into the cells), it is quite the potent antioxidant. But let’s get to the good stuff…<\/p>\r\n
A 2021 study showed Quercetin to do a whole host of things related to BAT\/brite activation. It increases expression of PGC-1a (necessary for brite conversion) and UCP1, reduces plasma cholesterol, increases expression of the elusive (in humans) B3 adrenoreceptor (which is a key in the whole package), and as well induces mitochondrial transcription factors. Best of all? It was also discovered to be a very potent PDE4D inhibitor (see the section on phosphodiesterases\/cAMP) and, less potently, a PDE3b inhibitor. Recall that both PDE3b inhibition and PDE4D inhibition are required for both browning and optimized non-shivering thermogenesis.<\/p>\r\n
As a side note, Quercetin decreases Firmicutes (starts with F for Fatty) to Bacteroides ratio in the gut, thus leading to a leaner phenotype expression.<\/p>\r\n
Now Quercetin, while relatively inexpensive, has horrible solubility in water and dismal oral absorption. The crystallization with Theobromine increases oral absorption substantially.<\/p>\r\n
Theobromine – Starting where we left off with Quercetin, Theobromine is ALSO quite a potent PDE4D inhibitor, the combination pretty much providing everything we need to preserve SNS cAMP signaling and optimized thermogenesis. But wait...there’s more!<\/p>\r\n
Theobromine is a major component of cocoa. It has been toyed with, mostly unsuccessfully, in fat burning formulas for decades. Knowing what we know now about mechanisms, it makes sense why it didn’t deliver as promised.<\/p>\r\n
Theobromine increases non-shivering thermogenesis, increases expression of PGC-1a, UCP1, other brite specific markers (we won’t be delving into those here quite yet) as well as increasing transport molecules like CPT1, which escorts shortened fatty acids from peroxisomes into the mitochondria for further beta-oxidation (and in our case, uncoupling\/heat production rather than ATP yield). In addition, Theobromine activates both B3 adrenoreceptors and AMPk, with the end result being a backblast of thermogenesis. As well, Theobromine suppresses preadipocyte differentiation, lipogenesis, and extends the browning effect to sub-mature adipocytes.<\/p>\r\n
Oleuropein 50%<\/p>\r\n
Oleuropein, contained in the olive plant, appears to be one of the main compounds contributing to the healthiness of the Mediterranean Diet. A unique compound, Oleuropein both dramatically increases UCP1 expression, and increases adrenaline\/noradrenaline secretion (absolutely essential for any kind of lipolysis, and therefore thermogenesis). Adrenaline\/noradrenaline acts as a ligand at the B3 adrenoreceptor (which, if you have been following has had both quantity increased as well as binding increased and signal amplified), the end result being hyperactivation of non-shivering thermogenesis.<\/p>\r\n
We mentioned BMP7 also being essential to brown\/brite thermogenesis. While we are using a 50% oleuropein extract here, the other polyphenols in Olive (the “other” 50%) have been demonstrated to increase expression of BMP7, thus completing the perfection of our formula.<\/p>\r\n
CONCLUSION<\/p>\r\n
As you can see, we have exhaustively targeted all of the known pathways of creating and activating brite cells in the body through either recruiting precursor cells or converting mature white cells. Regular supplementation should encourage fat loss and mimicking of a lean phenotype acutely, and even more so when taken chronically – as brite cells don’t immediately revert back to white adipose upon cessation of the product. BRITE is a long-term solution to an ongoing, serious problem plaguing modern society.<\/p>\r\n
<\/p>\r\n
<\/p>","gtin13":"0758381476494","image":["https:\/\/siteimgs.com\/10017\/item\/2brite_1703091174-0.jpg"],"brand":"EvoMuse","url":"https:\/\/www.dpsnutrition.net\/i\/33659\/evomuse-brite-capsules-120-cap.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"95.99","url":"https:\/\/www.dpsnutrition.net\/i\/33659\/evomuse-brite-capsules-120-cap.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/OutOfStock"}},{"@type":"Product","name":"SNS Serious Nutrition Solutions Lean GLP - 120 Capsules","sku":"SN153","description":"
Highlights\/Supports:<\/p>\r\n
<\/p>\r\n
In the world of ingredient science, beyond the hype and marketing, in a world guided by science and results rather than profit margins, there exist some very fascinating clinically researched ingredients that can help take your fat loss results to the next level.<\/p>\r\n
Lean GLP takes these ingredients and offers them all to you in 1 exciting product!<\/p>\r\n
Lean GLP contains 9 clinically researched ingredients including 8 branded ingredients, many of which have multiple patents on them related to improved glucose and lipid metabolism, healthy weight management, improved metabolic health, appetite control, fat loss, and improved body-composition.<\/p>\r\n
^^^ If you answered yes to any of these questions, meet your new weight loss companion, Lean GLP.<\/p>\r\n
Lean GLP is a true multi-faceted approach to fat loss & healthy weight management.<\/p>\r\n
If you want to support fat loss and healthy weight management in the most effective way possible, it’s important to target reducing fat storage and maximum fat loss in as many ways as possible.<\/p>\r\n
Multi-Faceted Approach to Fat Loss & Healthy Weight Management:<\/p>\r\n
As you can see, Lean GLP is very complex in how it is designed and is a true multi-faceted approach to fat loss and healthy weight management.<\/p>\r\n
The individual ingredient summaries later in this write up will provide more detailed information for those that are interested in the ingredient science and how each of the ingredients work.<\/p>\r\n
Lean GLP is about science and real world results – not overhyped marketing.<\/p>\r\n
Many dietary supplements are not designed the way that you may think that they are. Oftentimes, brands will determine a price point that they want a product to sell at and then work backwards figuring in their profit margin, overhead, and in today’s heavy advertising and marketing world, how much per bottle that they have to factor in to cost average in the price of advertising and paying influencers. For some marketing heavy brands, the advertising cost factored in per bottle may be even more than what the product actually costs to make. It’s an effective business model and it works well for a lot of brands, but the problem is that it often doesn’t leave room to use many, if any, very effective ingredients.<\/p>\r\n
SNS has always been a company that puts people before profits and science before hype.<\/p>\r\n
Lean GLP represents a tremendous opportunity to do this by offering the most comprehensive GLP-1 support supplement available!<\/p>\r\n
Lean GLP is a science driven formula that contains 9 clinically researched ingredients including 8 branded ingredients, many of which have multiple patents on them and have been shown in clinical studies to support improved glucose and lipid metabolism, healthy weight management, improved metabolic health, appetite control, fat loss, and improved body-composition.<\/p>\r\n
Body weight, metabolic health, and body-composition are important for so many things related to overall health, but one thing that is often overlooked is how important it is for mental health.<\/p>\r\n
We live in a world where sadly, the way that we look can influence how others look at us, judge us, and sometimes affect the opportunities that we do or don’t get because of our physical appearance. It’s sad and it shouldn’t be that way, but many people that struggle with body-weight issues unfortunately know that it is very much true, and it can take a toll on us – physically, mentally, and emotionally.<\/p>\r\n
Lean GLP is designed to help you reach your health and fitness goals, and to not only help you lose weight but to support healthy weight management and metabolic health so that you can look better, feel better, & perform better – AND most importantly, to help you feel better about yourself.<\/p>\r\n
GLP-1, or Glucagon-Like Peptide-1, is a hormone that plays a critical role in regulating blood sugar levels, appetite, and overall metabolism. Released by the gut in response to food intake, GLP-1 signals to your body that you are full and satisfied, helping to curb hunger and reduce food cravings. This powerful hormone also supports insulin production, helping the body utilize glucose more effectively, and plays a role in increasing fat burning.<\/p>\r\n
The body’s natural GLP-1 levels can oftentimes be insufficient to support lasting weight loss, especially with modern lifestyles that include high-calorie foods and stress.<\/p>\r\n
By helping to optimize GLP-1 activity, Lean GLP provides your body with powerful ingredients to help support appetite control, improve blood sugar regulation, and accelerate fat burning, making it easier to achieve and maintain your weight management goals.<\/p>\r\n
Lean GLP has contains multiple ingredients that have been shown to increase GLP1 levels. An increase in GLP-1 may translate into satiety (feeling fuller longer), less cravings, improved insulin sensitivity, healthy blood sugar levels, and enhanced fat-burning potential.<\/p>\r\n
A very important aspect of the Lean GLP formula is that it not only contains ingredients that have been shown to increase GLP-1 levels, but ingredients that have been shown to increase GLP-1 levels in a variety of different ways AND ingredients that have been shown to inhibit or decrease the activity of DPP-4, the enzyme that breaks down GLP-1.<\/p>\r\n
In simple terms, Lean GLP contains ingredients that have been shown to support an increase in GLP-1 secretion and ingredients that have been shown to help protect it from degradation.<\/p>\r\n
Here are some of the ways that the ingredients in Lean GLP may support increased levels of GLP-1:<\/p>\r\n
In addition, Lean GLP contains ingredients that have been shown to increase metabolism, burn fat, and support improved appetite control and reduced cravings through a variety of other pathways.<\/p>\r\n
GLP-1 is a hormone released in your digestive system after you eat to signal fullness and manage hunger, support digestion and support glucose metabolism. GLP-1 is essential for appetite regulation and plays multiple roles in metabolic health. Factors like age and lifestyle can affect your body’s ability to produce GLP-1, which is why we developed Lean GLP.<\/p>\r\n
Lean GLP is a daily use supplement to help support healthy GLP-1 levels and is also designed to help burn stored body fat and burn more calories in order to help you reach your lifestyle goals.<\/p>\r\n
Healthy diet & exercise will help optimize the effectiveness of any fat loss regimen.<\/p>\r\n
While the best type of diet & exercise may vary by the individual, some general suggestions would be to make sure that you drink enough water, reduce or eliminate sugary beverages (liquid calories), maintain healthy stress levels, be physically active, and get restful sleep.<\/p>\r\n
No, you do not have to work out to take Lean GLP.<\/p>\r\n
While working out can help burn more calories, burn fat, and is considered beneficial for overall health, everyone has individual factors that may influence their ability and time to work out. Whether it be going to the gym, working out at home, or something as simple as taking a walk around your yard or your home, it may be beneficial to do these things if you can do them, but that is related to a healthy lifestyle in general, not specific to Lean GLP.<\/p>\r\n
If you cannot, don’t lose hope because you can still get results. The way that many of the ingredients in Lean GLP work is not dependent on exercise.<\/p>\r\n
No, you do not have to do any certain type of diet to take Lean GLP.<\/p>\r\n
We live in a world where there are many different types of diets and a lot of people will argue that one or the other type of diet is better than the other, and then others may argue back that another type is better. The truth is that the best type of diet is the type that works best for you.<\/p>\r\n
Lean GLP is designed to help you stick to whatever plan that you choose that works best for you and to help you reach your goals more quickly.<\/p>\r\n
Lean GLP is a daily use supplement that can be taken for as long as you experience benefits. For best results, we suggest a minimum of 3-6 months of consistent daily use.<\/p>\r\n
Lean GLP contains 9 clinically researched ingredients, and studies on some of them have shown results in as little as a few weeks.<\/p>\r\n
Lean GLP is the first and only product to combine the power of all of these ingredients into one product, and people can expect to not only experience the benefits that all of these powerful ingredients can produce individually, but many of them will complement each other very well and lead to even more improved synergistic results.<\/p>\r\n
Most people will start to notice a reduction in appetite and reduced cravings for sweets within the first couple of weeks and will see their results become more pronounced and get better by the week as the ingredients build up in their system.<\/p>\r\n
Most people will start to see positive changes in the mirror and in their measurements within the first month, if not sooner, and will see their results become more visible as the ingredients build up in their system.<\/p>\r\n
For best results, we suggest using Lean GLP for at least 3 to 6 months.<\/p>\r\n
Lean GLP is formulated with 9 clinically researched ingredients including 8 branded ingredients, many of which have multiple patents on them related to healthy weight management, improved metabolic health, fat loss, and improved body-composition.<\/p>\r\n
Lean GLP can be taken by itself, or taken with certain other products that stack well with it in order to help you reach your individual health and body-composition goals.<\/p>\r\n
You don’t ‘need’ to take anything else with Lean GLP, but here are great options if you want to add additional supplements to help you burn fat and reach your goals faster.<\/p>\r\n
Lean Edge features an astounding 15 high end active fat burning ingredients and was designed with one goal in mind – to be the most comprehensive stimulant free fat burner available and burn fat through more different pathways than any other fat loss product on the market.<\/p>\r\n
Lean Edge stacks extremely well with Lean GLP for those wanting to maximize fat loss!<\/p>\r\n
Thermo Scorch is a multi-phase fat loss catalyst designed to help support fat loss through a variety of different pathways and help you lose fat fast! This exciting stimulant free fat burner helps burn body fat, increase caloric expenditure, and contains ingredients that mimic the effects of exercise!<\/p>\r\n
Thermo Scorch stacks extremely well with both Lean GLP and Lead Edge to help you target fat loss from as many different angles as possible in order to melt away stubborn body fat fast!<\/p>\r\n
Thermagize XT is the ultimate 1 capsule fat burning energizer available and is designed for people looking for a complete thermogenic fat loss formula that delivers fast acting, long lasting energy, mental focus, appetite control, & thermogenic metabolism accelerant properties.<\/p>\r\n
Lean Edge Nite Burn is a revolutionary nighttime fat burner and sleep aid and is a great product for people that struggle with nighttime hunger and waking up in the middle of the night and binge eating or breaking from their diet or healthy eating habits because of being half asleep (zombie eating as we not so affectionately like to call it). It’s really simple if you think about it – the average person sleeps 6 to 8 hours a night – that’s 1\/3 to 1\/4 of our day that we spend sleeping. Do you want to burn fat 2\/3 of the time or all of the time?<\/p>\r\n<\/div>","gtin12":"850008039270","image":["https:\/\/siteimgs.com\/10017\/item\/leanglp-front_1737988807-0.jpg","https:\/\/siteimgs.com\/10017\/item\/lean-glp-supp-facts_1737988811-0.jpg"],"brand":"SNS Serious Nutrition Solutions","url":"https:\/\/www.dpsnutrition.net\/i\/34836\/sns-serious-nutrition-solutions-lean-glp.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"59.99","url":"https:\/\/www.dpsnutrition.net\/i\/34836\/sns-serious-nutrition-solutions-lean-glp.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/InStock"}},{"@type":"Product","name":"SNS Serious Nutrition Solutions Lean GLP - 240 Capsules (2 x 120 Capsule Bottles) TWINPACK","sku":"SN2153","description":"
Highlights\/Supports:<\/p>\r\n
<\/p>\r\n
In the world of ingredient science, beyond the hype and marketing, in a world guided by science and results rather than profit margins, there exist some very fascinating clinically researched ingredients that can help take your fat loss results to the next level.<\/p>\r\n
Lean GLP takes these ingredients and offers them all to you in 1 exciting product!<\/p>\r\n
Lean GLP contains 9 clinically researched ingredients including 8 branded ingredients, many of which have multiple patents on them related to improved glucose and lipid metabolism, healthy weight management, improved metabolic health, appetite control, fat loss, and improved body-composition.<\/p>\r\n
^^^ If you answered yes to any of these questions, meet your new weight loss companion, Lean GLP.<\/p>\r\n
Lean GLP is a true multi-faceted approach to fat loss & healthy weight management.<\/p>\r\n
If you want to support fat loss and healthy weight management in the most effective way possible, it’s important to target reducing fat storage and maximum fat loss in as many ways as possible.<\/p>\r\n
Multi-Faceted Approach to Fat Loss & Healthy Weight Management:<\/p>\r\n
As you can see, Lean GLP is very complex in how it is designed and is a true multi-faceted approach to fat loss and healthy weight management.<\/p>\r\n
The individual ingredient summaries later in this write up will provide more detailed information for those that are interested in the ingredient science and how each of the ingredients work.<\/p>\r\n
Lean GLP is about science and real world results – not overhyped marketing.<\/p>\r\n
Many dietary supplements are not designed the way that you may think that they are. Oftentimes, brands will determine a price point that they want a product to sell at and then work backwards figuring in their profit margin, overhead, and in today’s heavy advertising and marketing world, how much per bottle that they have to factor in to cost average in the price of advertising and paying influencers. For some marketing heavy brands, the advertising cost factored in per bottle may be even more than what the product actually costs to make. It’s an effective business model and it works well for a lot of brands, but the problem is that it often doesn’t leave room to use many, if any, very effective ingredients.<\/p>\r\n
SNS has always been a company that puts people before profits and science before hype.<\/p>\r\n
Lean GLP represents a tremendous opportunity to do this by offering the most comprehensive GLP-1 support supplement available!<\/p>\r\n
Lean GLP is a science driven formula that contains 9 clinically researched ingredients including 8 branded ingredients, many of which have multiple patents on them and have been shown in clinical studies to support improved glucose and lipid metabolism, healthy weight management, improved metabolic health, appetite control, fat loss, and improved body-composition.<\/p>\r\n
Body weight, metabolic health, and body-composition are important for so many things related to overall health, but one thing that is often overlooked is how important it is for mental health.<\/p>\r\n
We live in a world where sadly, the way that we look can influence how others look at us, judge us, and sometimes affect the opportunities that we do or don’t get because of our physical appearance. It’s sad and it shouldn’t be that way, but many people that struggle with body-weight issues unfortunately know that it is very much true, and it can take a toll on us – physically, mentally, and emotionally.<\/p>\r\n
Lean GLP is designed to help you reach your health and fitness goals, and to not only help you lose weight but to support healthy weight management and metabolic health so that you can look better, feel better, & perform better – AND most importantly, to help you feel better about yourself.<\/p>\r\n
GLP-1, or Glucagon-Like Peptide-1, is a hormone that plays a critical role in regulating blood sugar levels, appetite, and overall metabolism. Released by the gut in response to food intake, GLP-1 signals to your body that you are full and satisfied, helping to curb hunger and reduce food cravings. This powerful hormone also supports insulin production, helping the body utilize glucose more effectively, and plays a role in increasing fat burning.<\/p>\r\n
The body’s natural GLP-1 levels can oftentimes be insufficient to support lasting weight loss, especially with modern lifestyles that include high-calorie foods and stress.<\/p>\r\n
By helping to optimize GLP-1 activity, Lean GLP provides your body with powerful ingredients to help support appetite control, improve blood sugar regulation, and accelerate fat burning, making it easier to achieve and maintain your weight management goals.<\/p>\r\n
Lean GLP has contains multiple ingredients that have been shown to increase GLP1 levels. An increase in GLP-1 may translate into satiety (feeling fuller longer), less cravings, improved insulin sensitivity, healthy blood sugar levels, and enhanced fat-burning potential.<\/p>\r\n
A very important aspect of the Lean GLP formula is that it not only contains ingredients that have been shown to increase GLP-1 levels, but ingredients that have been shown to increase GLP-1 levels in a variety of different ways AND ingredients that have been shown to inhibit or decrease the activity of DPP-4, the enzyme that breaks down GLP-1.<\/p>\r\n
In simple terms, Lean GLP contains ingredients that have been shown to support an increase in GLP-1 secretion and ingredients that have been shown to help protect it from degradation.<\/p>\r\n
Here are some of the ways that the ingredients in Lean GLP may support increased levels of GLP-1:<\/p>\r\n
In addition, Lean GLP contains ingredients that have been shown to increase metabolism, burn fat, and support improved appetite control and reduced cravings through a variety of other pathways.<\/p>\r\n
GLP-1 is a hormone released in your digestive system after you eat to signal fullness and manage hunger, support digestion and support glucose metabolism. GLP-1 is essential for appetite regulation and plays multiple roles in metabolic health. Factors like age and lifestyle can affect your body’s ability to produce GLP-1, which is why we developed Lean GLP.<\/p>\r\n
Lean GLP is a daily use supplement to help support healthy GLP-1 levels and is also designed to help burn stored body fat and burn more calories in order to help you reach your lifestyle goals.<\/p>\r\n
Healthy diet & exercise will help optimize the effectiveness of any fat loss regimen.<\/p>\r\n
While the best type of diet & exercise may vary by the individual, some general suggestions would be to make sure that you drink enough water, reduce or eliminate sugary beverages (liquid calories), maintain healthy stress levels, be physically active, and get restful sleep.<\/p>\r\n
No, you do not have to work out to take Lean GLP.<\/p>\r\n
While working out can help burn more calories, burn fat, and is considered beneficial for overall health, everyone has individual factors that may influence their ability and time to work out. Whether it be going to the gym, working out at home, or something as simple as taking a walk around your yard or your home, it may be beneficial to do these things if you can do them, but that is related to a healthy lifestyle in general, not specific to Lean GLP.<\/p>\r\n
If you cannot, don’t lose hope because you can still get results. The way that many of the ingredients in Lean GLP work is not dependent on exercise.<\/p>\r\n
No, you do not have to do any certain type of diet to take Lean GLP.<\/p>\r\n
We live in a world where there are many different types of diets and a lot of people will argue that one or the other type of diet is better than the other, and then others may argue back that another type is better. The truth is that the best type of diet is the type that works best for you.<\/p>\r\n
Lean GLP is designed to help you stick to whatever plan that you choose that works best for you and to help you reach your goals more quickly.<\/p>\r\n
Lean GLP is a daily use supplement that can be taken for as long as you experience benefits. For best results, we suggest a minimum of 3-6 months of consistent daily use.<\/p>\r\n
Lean GLP contains 9 clinically researched ingredients, and studies on some of them have shown results in as little as a few weeks.<\/p>\r\n
Lean GLP is the first and only product to combine the power of all of these ingredients into one product, and people can expect to not only experience the benefits that all of these powerful ingredients can produce individually, but many of them will complement each other very well and lead to even more improved synergistic results.<\/p>\r\n
Most people will start to notice a reduction in appetite and reduced cravings for sweets within the first couple of weeks and will see their results become more pronounced and get better by the week as the ingredients build up in their system.<\/p>\r\n
Most people will start to see positive changes in the mirror and in their measurements within the first month, if not sooner, and will see their results become more visible as the ingredients build up in their system.<\/p>\r\n
For best results, we suggest using Lean GLP for at least 3 to 6 months.<\/p>\r\n
Lean GLP is formulated with 9 clinically researched ingredients including 8 branded ingredients, many of which have multiple patents on them related to healthy weight management, improved metabolic health, fat loss, and improved body-composition.<\/p>\r\n
Lean GLP can be taken by itself, or taken with certain other products that stack well with it in order to help you reach your individual health and body-composition goals.<\/p>\r\n
You don’t ‘need’ to take anything else with Lean GLP, but here are great options if you want to add additional supplements to help you burn fat and reach your goals faster.<\/p>\r\n
Lean Edge features an astounding 15 high end active fat burning ingredients and was designed with one goal in mind – to be the most comprehensive stimulant free fat burner available and burn fat through more different pathways than any other fat loss product on the market.<\/p>\r\n
Lean Edge stacks extremely well with Lean GLP for those wanting to maximize fat loss!<\/p>\r\n
Thermo Scorch is a multi-phase fat loss catalyst designed to help support fat loss through a variety of different pathways and help you lose fat fast! This exciting stimulant free fat burner helps burn body fat, increase caloric expenditure, and contains ingredients that mimic the effects of exercise!<\/p>\r\n
Thermo Scorch stacks extremely well with both Lean GLP and Lead Edge to help you target fat loss from as many different angles as possible in order to melt away stubborn body fat fast!<\/p>\r\n
Thermagize XT is the ultimate 1 capsule fat burning energizer available and is designed for people looking for a complete thermogenic fat loss formula that delivers fast acting, long lasting energy, mental focus, appetite control, & thermogenic metabolism accelerant properties.<\/p>\r\n
Lean Edge Nite Burn is a revolutionary nighttime fat burner and sleep aid and is a great product for people that struggle with nighttime hunger and waking up in the middle of the night and binge eating or breaking from their diet or healthy eating habits because of being half asleep (zombie eating as we not so affectionately like to call it). It’s really simple if you think about it – the average person sleeps 6 to 8 hours a night – that’s 1\/3 to 1\/4 of our day that we spend sleeping. Do you want to burn fat 2\/3 of the time or all of the time?<\/p>\r\n<\/div>","gtin12":"850008039270","image":["https:\/\/siteimgs.com\/10017\/item\/leanglp-2_1737989134-0.jpg","https:\/\/siteimgs.com\/10017\/item\/lean-glp-supp-facts_1737988811-0.jpg"],"brand":"SNS Serious Nutrition Solutions","url":"https:\/\/www.dpsnutrition.net\/i\/34862\/sns-serious-nutrition-solutions-lean-glp.htm","offers":{"@type":"Offer","priceCurrency":"USD","price":"111.99","url":"https:\/\/www.dpsnutrition.net\/i\/34862\/sns-serious-nutrition-solutions-lean-glp.htm","itemCondition":"http:\/\/schema.org\/NewCondition","availability":"http:\/\/schema.org\/InStock"}},{"@type":"Product","name":"SNS Serious Nutrition Solutions Lean GLP - 360 Capsules (3 x 120 Capsule Bottles) 3 PACK","sku":"SN3153","description":"
Highlights\/Supports:<\/p>\r\n